The famed Flying Pussyfoot transcontinental train begins its storied voyage in Chicago in the early 1930s, leaving a trail of blood all throughout the country. At the same time, in New York, ambitious scientist Szilard and his unhappy sidekick Ennis are on the lookout for the immortality elixir's missing vials. In addition, a feud between mafia organizations is intensifying. Alchemists on board the Advena Avis in 1711 are about to discover the price of immortality. Baccano! is based on the award-winning light novels of the same name. chronicles a series of events that appear unrelated at first glance, both in terms of time and place, but are actually part of a much larger story about alchemy, survival, and immortality. Isaac, the kindhearted would-be thief, weaves these events together.